![]() NSAIDs may diminish the antihypertensive effect of ACE inhibitors. Coadministration may result in a significant decrease in renal function. Ibuprofen decreases effects of aspirin/citric acid/sodium bicarbonate by Other (see comment). The effect of other NSAIDs on aspirin is not established. Avoid or Use Alternate Drug.Ĭomment: Ibuprofen decreases the antiplatelet effects of aspirin by blocking the active site of platelet cyclooxygenase. Ibuprofen decreases effects of aspirin rectal by Other (see comment). ibuprofen increases toxicity of aspirin by anticoagulation. ![]() Administer ibuprofen 8 h before aspirin or at least 2-4 h after aspirin. Avoid or Use Alternate Drug.Ĭomment: Ibuprofen decreases the antiplatelet effects of low-dose aspirin by blocking the active site of platelet cyclooxygenase. Ibuprofen decreases effects of aspirin by Other (see comment). Ibuprofen and apixaban both increase anticoagulation. Each drug may increase the photosensitizing effect of the other. ![]() Avoid administering other phototoxic drugs with aminolevulinic acid oral for 24 hr during perioperative period.Įither increases toxicity of the other by pharmacodynamic synergism. Either increases toxicity of the other by pharmacodynamic synergism.
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